The 5-HTTLPR polymorphism and eating disorders: a meta-analysis
| Autor: | Maurizio Bellini, Alessandro Serretti, Raffaella Calati, Diana De Ronchi |
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| Přispěvatelé: | Calati, R, De Ronchi, D, Bellini, M, Serretti, A, Calati R., de Ronchi D., Bellini M., Serretti A. |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Genotype GENETIC bulimia nervosa Anorexia nervosa 5-HTTLPR anorexia nervosa Feeding and Eating Disorders Binge-eating disorder mental disorders medicine Humans Genetic Predisposition to Disease Psychiatry Alleles Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Bulimia nervosa serotonin transporter Publication bias medicine.disease META-ANALYSIS EATING DISORDERS Psychiatry and Mental health Eating disorders Endophenotype Meta-analysis eating disorder Psychology |
| Zdroj: | The International journal of eating disorders. 44(3) |
| ISSN: | 1098-108X |
| Popis: | Objective: Eating disorders are influenced by both environmental factors and genes. The 5-HTTLPR polymorphism of serotonin transporter gene has been suggested as a good candidate. This meta-analysis was undertaken: (1) to investigate the association between 5-HTTLPR and eating disorders considered as a whole, including anorexia (AN), bulimia (BN), and binge eating disorder (BED); (2) to extend recently reported findings on the association between 5-HTTLPR and AN-BN. Method: PubMed, ISI, and PsycINFO databases were searched for studies published until October 2009. Fifteen studies have been included. Data were analyzed with the Cochrane Collaboration Review Manager Software. Quality of studies and publication bias were assessed. Results: An association between S allele and eating disorders, in particular AN, has been found. Discussion: To be carrier of the 5-HTTLPR S allele seem to represent a risk factor for eating disorders, especially for AN. However, considering the reported high between-study heterogeneity, future studies should focus on more homogeneous endophenotype. (C) 2010 by Wiley Periodicals, Inc |
| Databáze: | OpenAIRE |
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