Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair
| Autor: | Song Li, Praneeth Janaswamy, Aijun Wang, Jeffrey J D Henry, Lawrence Delrosario, Randall J. Lee, Richard E. Sievers, Surya Kotha, Diana L. Farmer, Qizhi Fang, Sze Yue Wong, Jun Fang |
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| Rok vydání: | 2019 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Cardiotonic Agents Biomedical Engineering Myocardial Infarction Pharmaceutical Science Infarction 02 engineering and technology 010402 general chemistry 01 natural sciences Article Injections Biomaterials Contractility Rats Sprague-Dawley Fibrosis Pregnancy Internal medicine Materials Testing medicine Animals Humans Myocardial infarction Amnion Cells Cultured Glycosaminoglycans Decellularization Ejection fraction Tissue Engineering business.industry Myocardium Epithelial Cells Hydrogels 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Extracellular Matrix Heart failure Cardiology Cattle Female Collagen 0210 nano-technology business |
| Zdroj: | Adv Healthc Mater |
| ISSN: | 2192-2659 |
| Popis: | Ischemic heart disease represents the leading cause of death worldwide. Heart failure following myocardial infarction (MI) is associated with severe fibrosis formation and cardiac remodeling. Recently, injectable hydrogels have emerged as a promising approach to repair the infarcted heart and improve heart function through minimally invasive administration. Here, a novel injectable human amniotic membrane (hAM) matrix is developed to enhance cardiac regeneration following MI. Human amniotic membrane is isolated from human placenta and engineered to be a thermoresponsive, injectable gel around body temperature. Ultrasound-guided injection of hAM matrix into rat MI hearts significantly improves cardiac contractility, as measured by ejection fraction (EF), and decrease fibrosis. The results of this study demonstrate the feasibility of engineering as an injectable hAM matrix and its efficacy in attenuating degenerative changes in cardiac function following MI, which may have broad applications in tissue regeneration. |
| Databáze: | OpenAIRE |
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