Beta Carotene Modulates Nitric Oxide Production in the Renal Ischemia/Reperfusion Injury in Rat
| Autor: | Mohammad Kazem Gharib Naseri, Mohammad Badavi, Leila Pirmoradi, Foruzan Hosseini |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Kidney Renal ischemia business.industry Urinary system lcsh:R Ischemia lcsh:Medicine Pharmacology medicine.disease Nitric oxide 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine.anatomical_structure chemistry Renal blood flow Medicine Nitrite business Reperfusion injury |
| Zdroj: | Zahedan Journal of Researches in Medical Sciences, Vol 19, Iss 3 (2017) |
| ISSN: | 2383-2894 |
| DOI: | 10.5812/zjrms.7662 |
| Popis: | Background Renal ischemia and subsequent reperfusion injury is a major cause of acute renal failure and transplant rejection. Nitric oxide and its metabolites have important role in renal ischemia/reperfusion injury. Beta carotene as an antioxidant effectively scavenges toxic metabolites of nitric oxide. Our previous study has shown that beta carotene pretreatment protects kidney against ischemia/reperfusion injury. Objectives In this experimental study we investigated whether effect of beta carotene is causally linked with nitric oxide signal transduction. Methods In this experimental study, male adult Wistar rats (250 - 300 g) were exposed to 45 minutes of renal ischemia followed by 4 hours of reperfusion. Beta carotene (10, 30 and 100 mg kg-1) or vehicle was administered for 5 days prior to ischemia. Nitrite and nitrate were measured in the urine sample. Blood Flow and blood pressure were monitored during I/R period. Results I/R decreased (P < 0.001) urinary nitrite - nitrate and renal blood flow. Beta carotene pretreatment increased them (P < 0.05 - P < 0.001), although not by all doses. Blood pressure was not affected by beta carotene. Conclusions Since beta carotene administration improved renal blood flow and reduced the injury, it seems that beta carotene exerts some of its protective effects, probably by modulating of nitric oxide system. |
| Databáze: | OpenAIRE |
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