APOA5 Gene Variation Interacts with Dietary Fat Intake to Modulate Obesity and Circulating Triglycerides in a Mediterranean Population
| Autor: | Carmen Sánchez-Moreno, Jose M. Ordovas, Marta Garaulet, J. C. Baraza, Yu-Chi Lee, Caren E. Smith |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Population Medicine (miscellaneous) Single-nucleotide polymorphism Lipoproteins VLDL Overweight Biology Polymorphism Single Nucleotide Body Mass Index Young Adult Risk Factors Internal medicine medicine Humans Obesity Allele Promoter Regions Genetic education Apolipoproteins A Genetic Association Studies Triglycerides Aged Hypertriglyceridemia education.field_of_study Nutrition and Dietetics Mediterranean Region Middle Aged medicine.disease Dietary Fats Minor allele frequency Endocrinology Apolipoprotein A-V Cardiovascular Diseases Spain Female Nutrient Physiology Metabolism and Nutrient-Nutrient Interactions medicine.symptom Body mass index |
| Zdroj: | The Journal of Nutrition. 141:380-385 |
| ISSN: | 0022-3166 |
| DOI: | 10.3945/jn.110.130344 |
| Popis: | APOA5 is one of the strongest regulators of plasma TG concentrations; nevertheless, its mechanisms of action are poorly characterized. Genetic variability at the APOA5 locus has also been associated with increased cardiovascular disease risk; however, this predisposition could be attenuated in the context of a prudent diet as traditionally consumed in the Mediterranean countries. We have investigated the interaction between a single nucleotide polymorphism (SNP) at the APOA5 gene (-1131T . C) and dietary fat that may modulate TG-rich lipoprotein concentrations and anthropometric measures in overweight and obese participants. We recruited 1465 participants from a Spanish population (20–65 y old; BMI 25–40 kg/m 2 ) attending outpatient obesity clinics. Consistent with previous reports, we found an association between the APOA5-1131T . C SNP and TG-rich lipoprotein concentrations that were higher in carriers of the minor allele than in noncarriers (P , 0.001). Moreover, we found a significant genotype-dietary fat interaction for obesity traits. Participants homozygous for the 21131T major allele had a positive association between fat intake and obesity, whereas in those carrying the APOA521131C minor allele, higher fat intakes were not associated with higher BMI. Likewise, we found genotype-dietary fat interactions for TG-rich lipoproteins (P , 0.001). In conclusion, we have replicated previous gene-diet interactions between APOA5 -1131T . C SNP and fat intake for obesity traits and detected a novel interaction for TG-rich lipoprotein concentrations. Our data support the hypothesis that the minor C-allele may protect those consuming a high-fat diet from obesity and elevated concentrations of TG-rich lipoproteins. J. Nutr. doi: 10.3945/jn.110.130344. |
| Databáze: | OpenAIRE |
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