Establishment and validation of a nomogram for predicting overall survival of node-negative perihilar cholangiocarcinoma
| Autor: | Tian-Tian Gan, Chen-Song Huang, Li-jian Liang, Jian-Hui Li, Wei Chen, Xi-Tai Huang, Xiao-Yu Yin, Jian-Peng Cai |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Oncology
Multivariate statistics medicine.medical_specialty RD1-811 genetic structures urologic and male genital diseases Lower risk Nomogram Internal medicine Epidemiology medicine Humans Perihilar Cholangiocarcinoma Lymph node Neoplasm Staging AJCC staging system business.industry Prognosis Nomograms medicine.anatomical_structure Bile Duct Neoplasms Cohort Surgery Perihilar cholangiocarcinoma business Klatskin Tumor |
| Zdroj: | Asian Journal of Surgery, Vol 45, Iss 2, Pp 712-717 (2022) |
| ISSN: | 1015-9584 |
| DOI: | 10.1016/j.asjsur.2021.07.039 |
| Popis: | Aim: There lacks a predictive model for overall survival (OS) of node-negative perihilar cholangiocarcinoma (PHC). This study aimed at developing and validating a prognostic nomogram to predict OS of node-negative PHC after resection. Methods: We established a nomogram via multivariate regression analysis by using the design cohort (n = 410, obtained from Surveillance, Epidemiology, and End Results database), and its external verification was done in the validation cohort (n = 100, the First Affiliated Hospital of Sun Yat-sen University). Predictive accuracy of the nomogram was assessed by concordance-index (C-index), calibration curves, and decision curve analysis (DCA). Performance of the nomogram was compared with the American Joint Committee on Cancer (AJCC) staging system. Results: Multivariate regression analysis revealed that age, tumor grade, and the count of examined lymph nodes were independent prognostic factors for OS of node-negative PHC. The nomogram had a C-index of 0.603 and 0.626 in design cohort and validation cohort, respectively, which was better than that of AJCC staging system (both p |
| Databáze: | OpenAIRE |
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