Inhibition of Cryptosporidium parvum in vitro by 9-(Alkylthio)acridine Derivatives
| Autor: | Maria‐Jose Rosales, Nadia Bsiri, Latifa Khalifa, Jacques Barbe, Carmen Mascaro, Pierre Brouant, Janina Karolak-Wojciechowska |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Screening test Opportunistic infection Cryptosporidiosis Cell Line Microbiology Apicomplexa Feces Structure-Activity Relationship Drug Discovery medicine Animals Cryptosporidium parvum biology Chemistry Acridine derivatives Hydrogen Bonding Biological activity biology.organism_classification medicine.disease In vitro Animals Newborn Acridines Coccidiostats Protozoa Cattle |
| Zdroj: | Arzneimittelforschung. 50:163-166 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1300183 |
| Popis: | The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed. |
| Databáze: | OpenAIRE |
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