Intraarterial Infusion Chemotherapy and Radiotherapy With or Without Surgery for Patients With Locally Advanced or Recurrent Breast Cancer
| Autor: | Akira Sano, Takanori Taniguchi, Youichirou Kobashi, Yasumasa Kuroda, Yoshiaki Okamoto, Satoru Matsusue, Toshifumi Nakajima, Masao Murakami, Satoru Nishimura |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Mammary gland Breast Neoplasms Breast cancer Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Infusions Intra-Arterial Radical mastectomy Aged Neoplasm Staging Retrospective Studies Aged 80 and over Chemotherapy business.industry Radiotherapy Dosage Middle Aged Skin ulcer medicine.disease Combined Modality Therapy Survival Analysis Surgery Radiation therapy medicine.anatomical_structure Oncology Bone marrow suppression Female Neoplasm Recurrence Local medicine.symptom business |
| Zdroj: | American Journal of Clinical Oncology: Cancer Clinical Trials. 24:185-191 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-200104000-00017 |
| Popis: | We analyzed response, side effects, and local control rates of a multimodal treatment consisting of intraarterial infusion chemotherapy (IAIC) and radiotherapy with or without surgery for patients with locally advanced or recurred breast cancer. Thirty-three patients, clinically diagnosed as stage IIB in 1, IIIA in 2, IIIB in 12, IV in 18, were treated from 1991 to 1998. Twenty-five were primary and eight were recurrent cases after surgery. IAIC started as initial treatment up to three times maximum. In most cases, doxorubicin 50 mg, cisplatin 50 mg, and mitomycin 10 mg were infused in the subclavian and/or internal mammary artery. After IAIC, patients in primary cases underwent radical mastectomy or breast conservation surgery, after radiotherapy at a total dose of 50 Gy/25 fractions/5 weeks with a boost of 10 Gy. In recurrent cases, a full dose of radiotherapy was delivered. Clinical objective and complete response rates were 78% and 9% after IAIC. Despite a high rate of residual positive margin (67%) or clinically residual carcinoma, local recurrence developed only in 2 patients (6%) and local control rates at 5 years were calculated as 89%. Bone marrow suppression was frequent, and skin vesiculation (15%) and ulceration (9%) were experienced after IAIC. Skin ulcer (6%), brachial plexus neuropathy (3%), and radiation pneumonitis (3%) occurred as late toxicity. IAIC was effective as an induction treatment and radiotherapy played a role of local control for patients with locally advanced or recurrent breast cancer. |
| Databáze: | OpenAIRE |
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