Mantle Cell Lymphoma, 'Blastoid' Variant (WHO Classification), Producing Distinctive Morphologic Patterns
| Autor: | Joel A. Chan, Bharat N. Nathwani, Xiangdong Bu, Keith K. Lai |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Mantle zone Marginal zone Blastoid biology.organism_classification medicine.disease Pathology and Forensic Medicine Cyclin D1 immune system diseases Cytoplasm hemic and lymphatic diseases medicine Mantle cell lymphoma CD5 Mantle (mollusc) business |
| Zdroj: | Pathology Case Reviews. 7:88-96 |
| ISSN: | 1082-9784 |
| Popis: | Mantle cell lymphoma (MCL) comprises 7% of non-Hodgkin lymphomas. It can grow in several different architectural patterns including mantle zone, mantle cell nodular, follicular colonization, and diffuse. Cytologically, the mantle cell nuclei can range from round to slight to markedly irregular (classic), to blastoid, and to pleomorphic. They rarely have moderate amounts of cytoplasm and mimic marginal zone B cells. We present a most unusual case of MCL that displays mantle zone, mantle cell nodular, follicular colonization, marginal, inverse follicular, and interfollicular patterns. In the areas showing mantle zone, nodular, and follicular colonization, the mantle cells have round to slightly irregular nuclear contours, and show a high mitotic rate. In the areas displaying an interfollicular, inverse follicular, and marginal zone patterns, the mantle cells show selective transformation to large blastoid cells resembling lymphoblasts. The mitotic rate in these areas is exceedingly high. Immunophenotypically, both cytologic components are positive for CD20, CD5, CD43, and cyclin D1, confirming the MCL diagnosis. |
| Databáze: | OpenAIRE |
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