Swallow Tail Sign: Revisited
| Autor: | Malte Brammerloh, Evgeniya Kirilina, Anneke Alkemade, Pierre-Louis Bazin, Caroline Jantzen, Carsten Jäger, Andreas Herrler, Kerrin J. Pine, Penny A. Gowland, Markus Morawski, Birte U. Forstmann, Nikolaus Weiskopf |
|---|---|
| Přispěvatelé: | FMG, Brein en Cognitie (Psychologie, FMG), Brain and Cognition, Anatomie & Embryologie, RS: FHML non-thematic output |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Substantia Nigra
Sir Peter Mansfield Imaging Centre (SPMIC) Global Research Theme - Health and Wellbeing swallow tail sign Humans Radiology Nuclear Medicine and imaging Parkinson Disease Beacon - Precision Imaging Radiology medical physics neuroscience neurology MRI 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit IRC - Technological Innovations for Health & Wellbeing MRI scans |
| Zdroj: | Radiology, 305(3). Radiological Society of North America Inc. Radiology Radiology. Radiological Society of North America, Inc. |
| ISSN: | 0033-8419 1527-1315 |
| Popis: | The loss of the radiologic swallow tail sign on MRI scans of the substantia nigra is a promising diagnostic marker of Parkinson disease (1), although its anatom-ic underpinning is unclear. An early influential study showed that the hyperintense inner part of the swallow tail sign on T2*-weighted images (STh) corresponds to iron-poor areas in substantia nigra and suggested it to equal nigrosome 1, the dopaminergic region affected earliest and strongest in Parkinson disease (2). This would render the STh a cellularly specific marker (2). However, recent postmortem tissue studies have chal-lenged this interpretation, reporting that nigrosome 1 is hypointense in T2*-weighted images (3,4). We com-bined three-dimensional histology with 7-T in vivo and postmortem MRI to demonstrate that nigrosome 1 and the radiologic STh are partially overlapping but distinct. |
| Databáze: | OpenAIRE |
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