Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD
| Autor: | Souichi Shiratori, Katsuya Fujimoto, Kentaro Wakasa, Masahiro Asaka, Masato Obara, Takae Matsushita, Junichi Sugita, Mitsufumi Nishio, Haruhiko Kashiwazaki, Junji Tanaka, Tomoyuki Endo, Masahiro Imamura, Satoshi Hashino, Yusuke Shono, Akio Shigematsu, Makoto Ibata, Shojiro Takahashi, Takeshi Kondo, Mizuha Kosugi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning Adolescent folinic acid Leucovorin Graft vs Host Disease Gastroenterology stem cell transplantation Folinic acid Young Adult immune system diseases Internal medicine medicine Mucositis Humans Transplantation Homologous Young adult Aged Retrospective Studies Transplantation Stomatitis business.industry Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology Odds ratio Middle Aged medicine.disease Surgery Methotrexate Toxicity Female business Immunosuppressive Agents medicine.drug oral mucositis SCT |
| Zdroj: | Bone Marrow Transplantation. 47(2):258-264 |
| ISSN: | 0268-3369 |
| Popis: | Since the safety of folinic acid administration and its efficacy for reducing the toxicity of methotrexate (MTX) remain controversial, we assessed the effect of folinic acid administration after MTX treatment for GVHD prophylaxis on the incidence of oral mucositis and acute GVHD. We retrospectively analyzed data for 118 patients who had undergone allogeneic hematopoietic stem cell transplantation and had received MTX for GVHD prophylaxis. Multivariate analysis showed that systemic folinic acid administration significantly reduced the incidence of severe oral mucositis (OR = 0.13, 95%CI 0.04-0.73, P = 0.014). There was also a tendency for lower incidence of severe oral mucositis in patients who received folinic acid mouthwash (OR = 0.39, 95%CI 0.15-1.00, P = 0.051). No significant difference was observed in the incidence of acute GVHD between patients who received systemic folinic acid administration and those who did not (P = 0.88). Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic mucositis in patients who have received allogeneic hematopoietic stem cell transplantation using MTX as GVHD prophylaxis. |
| Databáze: | OpenAIRE |
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