Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer
| Autor: | Anupam Batra, C. Michael DiPersio, Anshu Aggarwal, David M. Jones, Rami N. Al-Rohil, Paul J. Feustel |
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| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty Invasive ductal carcinoma Cancer Research Gene Expression Breast Neoplasms macromolecular substances Metastasis Breast cancer Surgical oncology Internal medicine medicine Biomarkers Tumor Genetics Humans Clinical significance Neoplasm Metastasis Neoplasm Staging Tissue microarray business.industry PTGS2 Integrin alpha3beta1 Cancer medicine.disease Immunohistochemistry 3. Good health Tumor progression Cyclooxygenase 2 Cancer research Female Neoplasm Grading Neoplasm Recurrence Local business Integrin α3β1 COX2 Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-14-459 |
| Popis: | Background Expression of integrin α3β1 is associated with tumor progression, metastasis, and poor prognosis in several cancers, including breast cancer. Moreover, preclinical studies have revealed important pro-tumorigenic and pro-metastatic functions for this integrin, including tumor growth, survival, invasion, and paracrine induction of angiogenesis. Our previously published work in a preclinical breast cancer model showed that integrin α3β1 promotes expression of cyclooxygenase-2 (COX2/PTGS2), a known driver of breast cancer progression. However, the clinical significance of this regulation was unknown. The objective of the current study was to assess the clinical relevance of the relationship between integrin α3β1 and COX2 by testing for their correlated expression among various forms of human breast cancer. Methods Immunohistochemistry was performed to assess co-expression of α3 and COX2 in specimens of human invasive ductal carcinoma (IDC), either on a commercial tissue microarray (n = 59 samples) or obtained from Albany Medical Center archives (n = 68 samples). Immunostaining intensity for the integrin α3 subunit or COX2 was scored, and Spearman’s rank correlation coefficient analysis was performed to assess their co-expression across and within different tumor subtypes or clinicopathologic criteria. Results Although expression of integrin α3 or COX2 varied among clinical IDC samples, a statistically significant, positive correlation was detected between α3 and COX2 in both tissue microarrays (rs = 0.49, p |
| Databáze: | OpenAIRE |
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