Developmental differences in diffusion tensor imaging parameters in borderline personality disorder
| Autor: | Marianne Goodman, Antonia S. New, Uday Patil, M. Mercedes Perez-Rodriguez, Luis H. Ripoll, David Carpenter, Erin A. Hazlett, Jennifer Avedon |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Neural substrate Neuroimaging Development behavioral disciplines and activities Brain mapping Article Developmental psychology Diagnosis Differential White matter Young Adult 03 medical and health sciences 0302 clinical medicine Borderline Personality Disorder mental disorders Image Processing Computer-Assisted medicine Inferior longitudinal fasciculus Humans Young adult Borderline personality disorder Biological Psychiatry Brain Mapping Brain Reproducibility of Results medicine.disease 030227 psychiatry Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure nervous system Case-Control Studies Anisotropy Female Self Report Psychology 030217 neurology & neurosurgery Diffusion MRI Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 47:1101-1109 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2013.03.021 |
| Popis: | BackgroundBorderline personality disorder (BPD) often presents during adolescence. Early detection and intervention decreases its subsequent severity. However, little is known about early predictors and biological underpinnings of BPD. The observed abnormal functional connectivity among brain regions in BPD led to studies of white matter, as the neural substrate of connectivity. However, diffusion tensor imaging (DTI) studies in adult BPD have been inconclusive, and, as yet, there are no published DTI studies in borderline adolescents.MethodsWe conducted DTI tractography in 38 BPD patients (14-adolescents, 24-adults) and 32 healthy controls (13-adolescents, 19-adults).ResultsWe found bilateral tract-specific decreased fractional anisotropy (FA) in inferior longitudinal fasciculus (ILF) in BPD adolescents compared to adolescent controls. ILF FA was significantly higher in adolescent controls compared to BPD adolescents, BPD adults and adult controls (Wilks F(3,57) = 3.55, p |
| Databáze: | OpenAIRE |
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