Alkaloid Profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activity
| Autor: | Strahil Berkov, Nehir Unver Somer, B Bozkurt, Mustafa Ali Onur, Ahmet Emir, GI Kaya, Jaume Bastida |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Chromatography biology Chemistry Alkaloid Amaryllidaceae Biological activity 030204 cardiovascular system & hematology alkaloids biology.organism_classification Lycorine Mass spectrometry Acetylcholinesterase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Galanthus woronowii Pharmacology (medical) GC-MS General Pharmacology Toxicology and Pharmaceutics Gas chromatography–mass spectrometry Amaryllidaceae Alkaloids |
| Zdroj: | Marmara Pharmaceutical Journal. 21:915-920 |
| ISSN: | 1309-0801 |
| DOI: | 10.12991/mpj.2017.12 |
| Popis: | WOS: 000417369600022 The alkaloid profiles of the aerial parts and the bulbs of Galanthus woronowii Losinsk. were analyzed by means of Gas Chromatography-Mass Spectrometry (GC-MS). Totally, twenty-eight compounds were detected. Galanthamine and galanthine were found to be the main alkaloids both in the extracts of the aerial parts and the bulbs. Most of the identified compounds were lycorine and galanthamine-type Amaryllidaceae alkaloids. In addition, the acetylcholinesterase (AChE) inhibitor potentials of the extracts prepared from the aerial parts and bulbs were determined by in vitro Ellman's method and both of the extracts were found to exhibit significant activity (aerial parts: IC50 = 0.027 mu g/mL and bulbs: IC50 = 0.084 mu g/mL). Ege University Research FundEge University [09/ECZ/021, 09/ECZ/018]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [104T272] This study was financially supported by Ege University Research Fund (Project No: 09/ECZ/021 and 09/ECZ/018) and partially supported by TUBITAK (104T272). |
| Databáze: | OpenAIRE |
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