Inter-institutional survival heterogeneity in chemoradiation therapy for esophageal cancer: exploratory analysis of the JCOG0303 study

Autor: Ken Kato, Nobutoshi Ando, Satoshi Ishikura, Kenichi Nakamura, Hiroyasu Igaki, Yasuhiro Tsubosa, Yasuo Hamamoto, Hiroshi Katayama, Masayuki Shinoda, Junki Mizusawa, Haruhiko Fukuda, Yuko Kitagawa
Rok vydání: 2016
Předmět:
Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Esophageal Neoplasms
Short Communication
medicine.medical_treatment
Treatment outcome
Locally advanced
Drug Administration Schedule
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Neoplasm Staging
Cisplatin
business.industry
Confounding Factors
Epidemiologic
Radiotherapy Dosage
Chemoradiotherapy
General Medicine
Exploratory analysis
Middle Aged
Esophageal cancer
Prognosis
medicine.disease
Radiation therapy
Treatment Outcome
Fluorouracil
Lymphatic Metastasis
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
030211 gastroenterology & hepatology
Esophageal Squamous Cell Carcinoma
business
medicine.drug
Zdroj: Japanese Journal of Clinical Oncology. 46:389-392
ISSN: 1465-3621
0368-2811
DOI: 10.1093/jjco/hyv211
Popis: It is important to examine variation in the treatment effects of patients with esophageal cancer in order to generalize treatment outcomes. We aimed to investigate the range of prognostic differences among hospitals in the treatment of locally advanced esophageal cancer. The JCOG0303 study compared the efficacy of radiotherapy plus low-dose cisplatin and 5-fluorouracil with that of high-dose cisplatin and 5-fluorouracil for unresectable esophageal cancer. Of 32 institutions participating in the JCOG0303 study, the 18 institutions that enrolled three or more patients were included in this study. We predicted the 1-year survival in each institution by using a mixed-effect model. We found that the predicted 1-year survival in the 18 institutions with three or more patients was a median of 60.9%, with a range of 60.9–60.9%. This study is the first to investigated heterogeneity of survival in patients who received definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.
Databáze: OpenAIRE
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