Reproductive endocrine functions in men with primary hypothyroidism: effect of thyroxine replacement
| Autor: | M.G. Karmarkar, A.C. Ammini, Jaya Kumar, M.M.S. Ahuja, M.L. Khurana |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Chorionic Gonadotropin Endocrinology Sex hormone-binding globulin Hypothyroidism Semen Internal medicine Endocrine Glands Sex Hormone-Binding Globulin medicine Humans Euthyroid Testosterone Substitution therapy biology business.industry Primary hypothyroidism Middle Aged Thyroxine biology.protein Endocrine functions Gonadotropin Sex Hormone Binding Protein business hormones hormone substitutes and hormone antagonists Gonadotropins |
| Zdroj: | Hormone research. 34(5-6) |
| ISSN: | 0301-0163 |
| Popis: | Reproductive endocrine functions were studied in men with primary hypothyroidism during the hypothyroid phase and after achieving euthyroid status with thyroxine substitution therapy. Hypergonadotropism [luteinising hormone (LH), 18.7 +/- 7.3 IU/l; follicle-stimulating hormone (FSH), 6.3 +/- 2.0 IU/l], low serum testosterone (6.1 +/- 2.8 nmol/l), low serum sex-hormone-binding globulin (SHBG; 13.2 +/- 2.0 nmol/l) and subnormal testosterone response to human chorionic gonadotropin hCG; (30% increase in serum testosterone following hCG) observed during the hypothyroid phase were restored to normal (LH, 7.2 +/- 2.0 IU/l; FSH, 2.7 +/- 0.9 IU/l; testosterone, 12.9 +/- 2.7 nmol/l; SHBG, 26.5 +/- 8.4 nmol/l, and 2-fold increase in serum testosterone following hCG) with thyroxine substitution therapy. Some improvement in sperm count and motility was also observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|