Evidence for Nonesterified Fatty Acids as Modulators of Neutral Lipid Transfers in Normolipidemic Human Plasma
| Autor: | Valérie Guyard-Dangremont, Laurent Lagrost, Philippe Gambert, E. Florentin, Anne Athias, Christian Lallemant, Hassan Gandjini |
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| Rok vydání: | 1995 |
| Předmět: |
Very low-density lipoprotein
medicine.medical_specialty Fatty Acids Nonesterified Lipoproteins VLDL chemistry.chemical_compound NEFA Internal medicine Blood plasma Cholesterylester transfer protein medicine Humans Serum Albumin Triglycerides Glycoproteins chemistry.chemical_classification Triglyceride biology Fatty acid Biological Transport Lipids Cholesterol Ester Transfer Proteins Lipoproteins LDL Endocrinology chemistry biology.protein Cholesteryl ester lipids (amino acids peptides and proteins) Cholesterol Esters Carrier Proteins Lipoproteins HDL Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 15:1388-1396 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Abstract The relations between the level of plasma nonesterified fatty acid (NEFA) and both the mass concentration and activity of the cholesteryl ester transfer protein (CETP) were studied in fasted normolipidemic subjects. Plasma NEFA correlated positively with both CETP mass concentration ( r =.50; P HDL→VLDL+LDL activity) ( r =.46; P LDL→HDL activity) ( r =−.05; NS). The high binding capacity of albumin for NEFA was used to investigate whether lipoprotein-bound NEFAs were implicated in the modulation of the cholesteryl ester transfer reaction. As compared with nonsupplemented controls, the addition of an excess of fatty acid–free albumin (8 g/L) to total normolipidemic plasmas reduced CET HDL→VLDL+LDL activity (18.3±5.5% versus 9.8±3.1%; P LDL→HDL activity (22.3±4.5% versus 23.3±5.1%; NS). Moreover, CET HDL→VLDL+LDL and CET LDL→HDL activities correlated negatively when measured in native plasma ( r =−.45; P r =.40; P |
| Databáze: | OpenAIRE |
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