Follicular bronchiolitis in surgical lung biopsies: Clinical implications in 12 patients
| Autor: | Jay H. Ryu, Robert Vassallo, Jeffrey L. Myers, Rebecca M. Lindell, Michelle R. Aerni |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Biopsy Vital Capacity Interstitial lung disease Lung biopsy Desquamative interstitial pneumonia Biopsy lung Usual interstitial pneumonia Forced Expiratory Volume medicine Humans Lung Aged Aged 80 and over medicine.diagnostic_test business.industry Respiratory disease Undifferentiated connective tissue disease Middle Aged medicine.disease CT scan pulmonary Radiography Bronchiolitis Female Lymphocyte Radiology business |
| Zdroj: | Respiratory Medicine. 102(2):307-312 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2007.07.032 |
| Popis: | Summary Background Follicular bronchiolitis is a histopathologic finding that occurs in diverse clinical contexts. The current study was conducted to characterize clinico-radiologic features, and assess outcomes associated with follicular bronchiolitis. Subjects and methods Twelve subjects with follicular bronchiolitis on lung biopsy were seen over a 9-year period, between 1996 and 2005. Medical records, biopsy and radiographic findings, and details of outcome at the time of last follow-up were recorded. Results The study population included 4 men and 8 women; the median age at diagnosis was 54 years (range, 33–81 years). Four patients had underlying systemic diseases that included: 2 with common variable immunodeficiency, 1 Sjogren's syndrome and 1 undifferentiated connective tissue disease. The diagnosis was obtained by surgical lung biopsy in all cases. Follicular bronchiolitis was the major histologic pattern in 9 patients; organizing pneumonia, nonspecific interstitial pneumonia and usual interstitial pneumonia was seen in 1 patient each with follicular bronchiolitis being an associated secondary histopathologic component. Computed tomographic findings included reticular opacities, small nodules and ground-glass opacities. Clinical course was characterized by relative stability with partial response to immunosuppressive agents. During a median follow-up period of 47 months, only one death occurred—out of 9 patients where the outcome information was available—and was unrelated to lung disease. Conclusions The histologic lesion of follicular bronchiolitis may be seen as the predominant finding or a relatively minor feature in interstitial pneumonias. The clinical course and prognosis for most patients with follicular bronchiolitis is relatively good, and progressive lung disease is uncommon. |
| Databáze: | OpenAIRE |
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