Determination of N-(3-acetamidopropyl)pyrrolidin-2-one, a metabolite of spermidine, in urine by isotope dilution mass fragmentography
| Autor: | H Elzinga, Gita A. van den Berg, Anneke W. Kingma, Frits A. J. Muskiet |
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| Přispěvatelé: | Analytical Biochemistry |
| Jazyk: | angličtina |
| Rok vydání: | 1986 |
| Předmět: |
Adult
Quality Control Adolescent Spermidine Metabolite Urine Isotope dilution Mass spectrometry Gas Chromatography-Mass Spectrometry Mass fragmentography chemistry.chemical_compound Reference Values Humans Child Aged Chromatography Lymphoma Non-Hodgkin Infant General Chemistry Middle Aged Pyrrolidinones chemistry Child Preschool Indicators and Reagents Gas chromatography Conjugate |
| Zdroj: | Journal of Chromatography A, 383(2), 251-258. ELSEVIER SCIENCE BV |
| ISSN: | 0021-9673 |
| Popis: | A capillary gas chromatographic method with mass spectrometric detection for the determination of N-(3-acetamidopropyl)pyrrolidin-2-one, the monoacetyl conjugate of isoputreanine-γ-lactam, in urine has been developed. Using a quantification based on stable isotope dilution mass fragmentography, age-dependent normal values for the urinary excretion of N-(3-acetamidopropyl)pyrrolidin-2-one by 44 apparently healthy control subjects were determined. Quality control data and normal values for 27 adults are given. The method was applied to the monitoring of the chemotherapeutic treatment of two patients with high-grade non-Hodgkin lymphoma. |
| Databáze: | OpenAIRE |
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