C-5a-substituted validamine type glycosidase inhibitors

Autor:	Roland Fischer, Michael Schalli, Stephen G. Withers, Christina Tysoe, Martin Thonhofer, Andrés G. Santana, Andreas Wolfsgruber, Arnold E. Stütz
Rok vydání:	2017
Předmět:	0301 basic medicine Stereochemistry Agrobacterium Saccharomyces cerevisiae 01 natural sciences Biochemistry Analytical Chemistry Fungal Proteins 03 medical and health sciences chemistry.chemical_compound Bacterial Proteins Carbohydrate Conformation Escherichia coli Animals Glycoside hydrolase Enzyme Inhibitors 010405 organic chemistry beta-Glucosidase Organic Chemistry Glycosidase inhibitor General Medicine beta-Galactosidase Validamine 0104 chemical sciences Aminocyclitol Kinetics 030104 developmental biology chemistry Cattle Hydrophobic and Hydrophilic Interactions Inositol
Zdroj:	Carbohydrate Research. :1-9
ISSN:	0008-6215
DOI:	10.1016/j.carres.2017.01.006
Popis:	A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc0e5b2401c0da8fd29b7f7de47576a https://doi.org/10.1016/j.carres.2017.01.006 Zobrazit plný text záznamu Full Text from ScienceDirect