Ultrastructural Analysis of Urethral Polyps against the Background of Urogenital Infection
| Autor: | A. I. Neimark, O. P. Molodykh, M. A. Bakarev, G. A. Lapii, A. V. Yakovlev |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Connective tissue Trichomonas Infections Chlamydia trachomatis Mycoplasma genitalium Peripheral blood mononuclear cell Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Polyps Urethral Diseases medicine Trichomonas vaginalis Humans In patient Mycoplasma Infections Urethral Neoplasms business.industry Genitourinary system Ureaplasma Infections Mean age General Medicine Chlamydia Infections Middle Aged Epithelium medicine.anatomical_structure Urinary Tract Infections Ultrastructure Female Urothelium business Ureaplasma urealyticum Infectious agent |
| Zdroj: | Bulletin of experimental biology and medicine. 167(6) |
| ISSN: | 1573-8221 |
| Popis: | We performed an electron microscopic study of samples of urethral polyps obtained from 90 women (mean age 52.5±4.9 years). According to PCR and culture studies, the most common infectious agent in patients with urethral polyps is U. urealyticum (100% cases). In 70% cases, this infectious agent was present as monoinfection, of these, clinically significant concentration (>106 CFU/ml) were found in 53.3% cases. In 30% cases, associations with C. trachomatis, T. vaginalis, and M. genitalium were found. We observed significant ultrastructural heterogeneity of the epithelial cells in urethral polyps, which manifested in a combination of hyperplastic and metaplastic changes and signs of cytodestruction. Detection of mycoplasma-like bodies in connective tissue mononuclear cells and viral particles in epithelial cells during ultrastructural study, including cases with negative PCR results, indicates the pathogenetic role of latent infection in the formation of urethral polyps. |
| Databáze: | OpenAIRE |
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