Protective effects of polymethoxyflavone-rich cold-pressed orange peel oil against ultraviolet B-induced photoaging on mouse skin
| Autor: | Guolu Liang, Xin Zhao, Manjiao Liu, Yujiao Cheng, Houjiu Wu, Xiaochun Zhao, Qunlin Zhang, Qi Zhou, Fang Tan, Russell L. Rouseff, Xiang Tan, Tan Anqun, Linhua Huang, Guijie Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Skin photoaging Photoaging Medicine (miscellaneous) Orange (colour) Matrix metalloproteinase Superoxide dismutase 03 medical and health sciences Hydroxyproline chemistry.chemical_compound 0404 agricultural biotechnology medicine Methoxyflavones TX341-641 chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics integumentary system biology Nutrition. Foods and food supply Glutathione peroxidase 04 agricultural and veterinary sciences medicine.disease 040401 food science Molecular biology Orange peel cold-pressed oil chemistry Oxidative stress Catalase biology.protein Ultraviolet B Type I collagen Food Science |
| Zdroj: | Journal of Functional Foods, Vol 67, Iss, Pp 103834-(2020) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2020.103834 |
| Popis: | The protective effects of the topical application of orange peel cold-pressed oil (CPO), a rich polymethoxyflavones (PMFs) source, on ultraviolet B (UVB)-induced skin injury were studied. Depilated KM mice were irradiated by UVB at one minimal erythemal dose every day and the treated groups were smeared with CPO before radiation. After two weeks we found that CPO helped to maintain the dermal structure and enhanced serum levels and skin tissue expression of superoxide dismutase, catalase and glutathione peroxidase. In serum CPO lowered interleukin-6/-1β and tumor necrosis factor α levels; in skin it decreased the levels of type III collagen and H2O2 but increased hydroxyproline and type I collagen. Moreover, the skin expression of matrix metalloproteinases 2/9 was downregulated, whereas the expression of tissue inhibitor of metalloproteinases 1/2 was upregulated. The above effects followed a dose-dependent manner. Liquid chromatography analysis of irradiated skin tissue showed partial decomposition of PMFs into 5-hydroxy-PMFs. |
| Databáze: | OpenAIRE |
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