Single-Run Separation of Closely Related Cationic and Anionic Compounds by CE-ESI-MS: Application to the Simultaneous Analysis of Melamine and its Analogs in Milk

Autor: Jean-Luc Veuthey, Ivano Marchi, Emmanuelle Cognard, Julie Schappler, Didier Ortelli, Patrick Edder, Serge Rudaz, Isabelle Kohler
Jazyk: němčina
Rok vydání: 2011
Předmět:
Zdroj: CHIMIA, Vol 65, Iss 6 (2011)
Chimia, Vol. 65, No 6 (2011) pp. 389-395
ISSN: 2673-2424
0009-4293
Popis: In recent years, two adulteration incidents concerning the addition of melamine, a nitrogen-rich-industrial small polar compound, to pet food and infant formula products have occurred in China. These issues prompted laboratories to develop methods for the analysis of melamine and related compounds in a wide variety of food products and ingredients. In this context, a CE-ESI-MS method was developed to simultaneously analyze melamine and its related products (ammeline, ammelide and cyanuric acid) that possess close physico-chemical properties. This method allows the simultaneous analysis of both cations and anions in a single run, using CE to divide the run into two time segments in normal polarity mode. For this purpose, ESI polarity was switched once during the run, increasing sensitivity and data quality. The method was applied to spiked powdered milk and melamine-contaminated powdered milk, with two sample preparation procedures.
Databáze: OpenAIRE