Impact of placental Plasmodium falciparum malaria infection on the Cameroonian maternal and neonate’s plasma levels of some cytokines known to regulate T cells differentiation and function
| Autor: | Stalone Siewe Siewe, Edwige Vanessa Chomga Foko, Rosette Megnekou, Jean Claude Djontu, Benderli Christine Nana, Jude D. Bigoga, Yolande Delphine Mpeke Edene, Rose F. G. Leke |
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| Jazyk: | angličtina |
| Předmět: |
Adult
0301 basic medicine Placenta Diseases Adolescent T-Lymphocytes Birth weight Plasmodium falciparum Biology Andrology Plasma Young Adult 03 medical and health sciences Placental malaria Pregnancy Placenta Immune Tolerance medicine Humans Cameroon Malaria Falciparum Pregnancy Complications Infectious Univariate analysis Research Pregnant women Infant Newborn medicine.disease biology.organism_classification Peripheral Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Infectious Diseases Parasitology Cord blood Immunology Cytokines Female Malaria |
| Zdroj: | Malaria Journal |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/s12936-016-1611-0 |
| Popis: | Background The impact of placental malaria (PM) infection on the expression profile of some cytokines known to regulate T cell differentiation and function and their influence on birth weight remain unclear. Moreover, there are no reports showing the relationship between PM and IL-27 or IL-28A. This study therefore sought to investigate whether placental P. falciparum infection alters the expression profile of the cytokines IL-28A, IL-27, IL-17E and IL-6 in mothers and their new born. Methods In a cross-sectional study conducted between 2013 and 2015 in Yaoundé, Cameroon, peripheral, placental and cord blood samples were collected from 108 women at delivery. Parasitaemia was determined microscopically and haemoglobin levels determined using a Coulter counter. Plasma levels of cytokines (IL-28A, IL-27, IL-17E and IL-6) were measured by Luminex magnetic screening assay. Results Malaria parasite density in placenta impression smear associated negatively with maternal haemoglobin level (P |
| Databáze: | OpenAIRE |
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