Decreased Intensity of Inflammation in Benznidazole-Treated Mice Inoculated with Trypanosoma cruzi I Stocks from Mexico and Persistence of Circulating Parasites
| Autor: | Rodolfo Enrique del Rio-Rodriguez, Guillermo Cruz-Zetina, Victor M. Monteón, Angel Ramos-Ligonio, Ruth López |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Chagas disease
Genotype Trypanosoma cruzi Inflammation Parasitemia Biology Polymerase Chain Reaction Persistence (computer science) law.invention Mice law Virology parasitic diseases medicine Animals Chagas Disease Muscle Skeletal Mexico Polymerase chain reaction Trypanocidal agent Mice Inbred BALB C Heart Articles medicine.disease biology.organism_classification Trypanocidal Agents Infectious Diseases Nitroimidazoles Benznidazole Parasitology medicine.symptom Cardiomyopathies medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 87:671-674 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2012.11-0519 |
| Popis: | We analyzed the intensity of inflammation and parasitism in BALB/c mice infected with Trypanosoma cruzi I stocks from Mexico with and without benznidazole treatment in the acute phase of disease. Heart and skeletal muscles were evaluated for parasites and inflammation and blood was evaluated for persistence of circulating parasites. Parasitemia was influenced by T. cruzi stocks used and benznidazole treatment. This treatment cleared circulating parasites three days after starting treatment when monitored by direct microscopy. There was a significant reduction of inflammation in skeletal muscles after benznidazole treatment in animals infected with Mexican T. cruzi I stocks (P < 0.05), but this reduction was not significant in the heart (P > 0.05). Trypanosoma cruzi I parasites from Mexico were demonstrated by polymerase chain reaction in tissues and blood of animals after benznidazole treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|