NNRTI-based antiretroviral therapy may increase risk of radiation induced side effects in HIV-1-infected patients
| Autor: | Harrer Thomas, Hecht Markus, Harrer Ellen, Keller Ulrike, Schuster Barbara, Fietkau Rainer, Luitpold Distel |
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| Rok vydání: | 2015 |
| Předmět: |
Risk
Oncology medicine.medical_specialty Efavirenz Anti-HIV Agents DNA repair medicine.medical_treatment HIV Infections Emtricitabine Radiation Tolerance Ionizing radiation chemistry.chemical_compound immune system diseases Antiretroviral Therapy Highly Active Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Lymphocytes Radiosensitivity Chromosome Aberrations business.industry Incidence (epidemiology) virus diseases Cancer Hematology medicine.disease Radiation therapy chemistry Immunology HIV-1 business medicine.drug |
| Zdroj: | Radiotherapy and Oncology. 116:323-330 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2015.07.002 |
| Popis: | Purpose As the incidence of cancer is rising in HIV-1-infected patients, radiotherapy is used more frequently in this patient group. Strong radiation induced side effects have been reported in single patients on antiretroviral therapy. Thus we investigated whether HIV-1 itself or antiretroviral drugs could enhance radiosensitivity in patients. Methods and materials Radiosensitivity after in vitro irradiation of blood lymphocytes was tested in 196 individuals (80 HIV-1-infected patients and 116 healthy controls and cancer patients) using a three color fluorescence in situ hybridization approach to analyze chromosomal aberrations (B/M). Additionally, the NNRTI efavirenz and the NRTIs tenofovir and emtricitabine were tested for radiosensitizing effects in vitro. Results Lymphocytes from HIV-1-infected patients in the NNRTI+NRTI group were significantly more sensitive to ionizing radiation than in the other groups (patients without treatment or with NRTI+PI or HIV-negative controls). In vitro the triple medication efavirenz, tenofovir and emtricitabine leads to a reduced survival fraction and an increased activation of the DNA repair proteins H2AX, Nbs, Atm and 53BP1 in combination with ionizing radiation. Conclusions HIV-1 treatment with NNRTI containing therapy regimes possibly sensitizes a subgroup of patients to ionizing radiation. Individual radiosensitivity of HIV-1-infected patients on HAART including NNRTI should be tested before starting radiotherapy. |
| Databáze: | OpenAIRE |
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