Influence of Aging on Ethanol and Acetaldehyde Oxidation in Female Rat Liver
| Autor: | Cynthia D. Snowden, Lora E. Rikans, Danny R. Moore |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Aging
medicine.medical_specialty Aldehyde dehydrogenase Mitochondria Liver Acetaldehyde Microsomal ethanol oxidizing system chemistry.chemical_compound Cytosol Cytochrome P-450 Enzyme System Glutamate Dehydrogenase Internal medicine medicine Animals Ethanol metabolism Alcohol dehydrogenase Ethanol biology Glutamate dehydrogenase Alcohol Dehydrogenase Aldehyde Dehydrogenase Catalase Rats Inbred F344 Rats Alcohol Oxidoreductases Endocrinology Liver chemistry Cyanamide biology.protein Female Geriatrics and Gerontology Oxidation-Reduction |
| Zdroj: | Gerontology. 36:185-192 |
| ISSN: | 1423-0003 0304-324X |
| DOI: | 10.1159/000213198 |
| Popis: | Rates of ethanol metabolism by alcohol dehydrogenase, the microsomal ethanol oxidizing system (MEOS), and catalase were similar in liver preparations from young (4-5 months) and old (24-27 months) female Fischer 344 rats. On the other hand, rates of acetaldehyde metabolism by mitochondrial aldehyde dehydrogenase (ALDH) were 15-20% lower in livers of old rats than in those of younger ones. Results with the ALDH inhibitor cyanamide indicated that a decline in ALDH activity of this magnitude would not increase acute ethanol hepatotoxicity. |
| Databáze: | OpenAIRE |
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