Early prediction of donepezil cognitive response in Alzheimer's disease by brain perfusion single photon emission tomography

Autor: Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Buntipa Natsawang, Sookjaroen Tangwongchai, Patrick Dupont, Solaphat Hemrungrojn, Daruj Aniwattanapong, Itthipol Tawankanjanachot, Yuttachai Likitjareon, Natakorn Siritranon, Phenphichcha Chuchuen, Supatporn Tepmongkol
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Cognitive Neuroscience
Perfusion scanning
Neuropsychological Tests
Statistical parametric mapping
050105 experimental psychology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Cognition
Neuroimaging
Alzheimer Disease
Internal medicine
mental disorders
medicine
Dementia
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Donepezil
Neuropsychological assessment
Aged
Tomography
Emission-Computed
Single-Photon
medicine.diagnostic_test
business.industry
05 social sciences
Brain
Middle Aged
medicine.disease
Psychiatry and Mental health
Neurology
Cerebral blood flow
Cardiology
Female
sense organs
Neurology (clinical)
Cholinesterase Inhibitors
business
Perfusion
030217 neurology & neurosurgery
medicine.drug
Zdroj: Brain imaging and behavior. 13(6)
ISSN: 1931-7565
Popis: Currently, there is no effective means to evaluate donepezil response. We evaluated brain perfusion change at 4 h after donepezil administration (4 h DNPZ) to predict cognitive responses after 6 months of medication. CERAD neuropsychological assessment battery was used to define cognitive response at 6 months. We compared 4 h DNPZ to baseline single photon emission tomography (SPECT) by statistical parametric mapping to identify perfusion changes in responders (N = 16) and non-responders (N = 7). In responders, there were significant relatively increase in perfusion in left parietal lobe (BA39, 7, 1), right superior frontal gyrus (BA6) and right middle occipital gyrus (BA39). In the non-responders, perfusion was relatively increase in the left parietal lobe (BA39) only. In an explorative analysis, we found a significant correlation between perfusion changes in right BA6 and CERAD score changes at 6 months. Different SPECT perfusion changes at 4 h after donepezil administration were demonstrated in the group of responders and non-responders with potential correlation with CERAD score change. Thus, 4 h DNPZ brain perfusion SPECT can be used to predict donepezil response at 6 months.
Databáze: OpenAIRE
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