Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis
| Autor: | Louise Grahnemo, Jan Borén, Staffan Nilsson, John-Olov Jansson, Maria E. Johansson, Sara L. Svahn, Marcus A. Ulleryd, Marcus Ståhlman |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Staphylococcus aureus medicine.drug_class Immunology Antibiotics Adipose tissue Inflammation Biology medicine.disease_cause Staphylococcal infections Microbiology Sepsis 03 medical and health sciences Mice Random Allocation 0302 clinical medicine Internal medicine Fatty Acids Omega-3 medicine Animals chemistry.chemical_classification digestive oral and skin physiology Fatty Acids Fatty acid nutritional and metabolic diseases food and beverages Bacterial Infections Staphylococcal Infections medicine.disease Bacterial Load 030104 developmental biology Infectious Diseases Endocrinology chemistry Adipose Tissue 030220 oncology & carcinogenesis Cytokines Parasitology medicine.symptom Polyunsaturated fatty acid |
| Popis: | Sepsis caused by Staphylococcus aureus is increasing in incidence. With the alarming use of antibiotics, S. aureus is prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival of S. aureus -induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival of S. aureus -induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation with S. aureus . Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S after S. aureus -induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S after S. aureus -induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of S. aureus -induced sepsis by reversing the deleterious effect of HFD-S on mouse survival. |
| Databáze: | OpenAIRE |
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