DESENSITIZATION OF β-ADRENORECEPTORS IN GUINEA-PIG TRACHEA: A PROSTAGLANDIN MEDIATED PHENOMENON
| Autor: | Giancarlo Folco, T. Viganò, Luisa Daffonchio, Claudio Omini, Ferruccio Berti |
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| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic receptor Muscle Relaxation Guinea Pigs Indomethacin Drug Resistance Prostaglandin Tachyphylaxis Guinea pig chemistry.chemical_compound Desensitization (telecommunications) Internal medicine Isoprenaline Receptors Adrenergic beta medicine Animals Humans Pharmacology Relaxation (psychology) Prostaglandins E General Neuroscience Isoproterenol respiratory system Receptors Adrenergic Trachea Endocrinology chemistry Pilocarpine lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Journal of Autonomic Pharmacology. 2:247-253 |
| ISSN: | 1365-2680 0144-1795 |
| Popis: | 1 The formation and release of PGE2-like material (PGE2-lm) from guinea-pig isolated trachea and human bronchi following relaxation with isoprenaline (I) was investigated. 2 When airway smooth muscle precontracted with pilocarpine is relaxed by I, PGE2-lm is released in the bathing fluid. Under conditions of β-adrenoreceptor desensitization, a greater amount of PGE2-lm is formed and the responsiveness of guinea-pig tracheal spirals to cumulative doses of I is diminished. 3 Inhibition of cyclo-oxygenase with indomethacin does not modify the relaxation induced by I but prevents the occurrence of refractoriness to I as well as formation and release of PGE2-lm. Addition of exogenous PGE2 to guinea-pig tracheas which were treated with indomethacin is able to restore the capacity of I to cause tachyphylaxis. 4 It is concluded that PGE2 which does not mediate the relaxation induced by I in airway smooth muscle, is responsible for the onset of desensitization of the β-adrenoreceptor. |
| Databáze: | OpenAIRE |
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