Role of lung ultrasound in the assessment of recruitment maneuvers in ventilated preterm neonates with respiratory distress syndrome and its correlation with tracheal IL-6 levels: A randomized controlled trial
| Autor: | M O Dawoud, Hani A. Awad, N T Ahmed, N M Abushady, E M Fouda, D R Kamel |
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| Rok vydání: | 2020 |
| Předmět: |
Randomization
Mean airway pressure law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Intensive care medicine Humans 030212 general & internal medicine Child Lung Ultrasonography Respiratory Distress Syndrome Respiratory Distress Syndrome Newborn Respiratory distress business.industry Interleukin-6 Area under the curve Infant Newborn medicine.anatomical_structure 030228 respiratory system Anesthesia Pediatrics Perinatology and Child Health Breathing business |
| Zdroj: | Journal of neonatal-perinatal medicine. 14(3) |
| ISSN: | 1878-4429 |
| Popis: | BACKGROUND: This study’s aim is to evaluate lung ultrasound (LUS) efficacy in detecting opening and closing lung pressures and its correlation with the tracheal interleukin 6 (IL-6) level. METHOD: This single-blinded randomized controlled study was done at Ain Shams University Children’s Hospital neonatal intensive care units, Egypt. It consists of 44 mechanically ventilated preterm neonates with Respiratory Distress Syndrome (RDS). Initial LUS assessment was done followed by randomization to one of 2 groups; group I: 22 patients underwent LUS guided RM and group II: 22 patients underwent non-ultrasound guided RM. Tracheal IL-6 level was measured before and after RM in both groups. RESULTS: The LUS scores showed a sensitivity of 86.7%, specificity of 62.10% and accuracy of 70.45% at the cut-off point >B1 grade. After RM, there was a higher percentage of changes in mean airway pressure (p = 0.03), FiO2 (p = 0.01), PaO2/FiO2 ratio (p = 0.01), and IL-6 (p 21 with a sensitivity of 75%, specificity of 71.43% and area under the curve of 78.1%. CONCLUSION: LUS-guided RM achieved earlier lowest FiO2, shorter O2 dependency, lesser NICU stay and marked decrease in lung inflammation by decreasing atelectotrauma and shortening the duration of invasive ventilation. |
| Databáze: | OpenAIRE |
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