Long noncoding RNAs: new insights in modulating mammalian spermatogenesis
| Autor: | Shan-Jiang Zhao, Xiuge Wang, Jinming Huang, Bahlibi Weldegebriall Sahlu, Huabin Zhu, Saqib Umer, Huiying Zou |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Large class Review Regulatory pathways Biology Biochemistry Genome 03 medical and health sciences 0302 clinical medicine Spermatocytes Gene expression medicine Mammalian spermatogenesis lcsh:SF1-1100 lcsh:Veterinary medicine Long non-coding RNA Cell biology 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis lcsh:SF600-1100 Animal Science and Zoology lcsh:Animal culture Germ cell Spermatogenesis Long noncoding RNA Food Science Biotechnology |
| Zdroj: | Journal of Animal Science and Biotechnology, Vol 11, Iss 1, Pp 1-12 (2020) Journal of Animal Science and Biotechnology |
| ISSN: | 2049-1891 |
| DOI: | 10.1186/s40104-019-0424-8 |
| Popis: | Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis. |
| Databáze: | OpenAIRE |
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