Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic : a cross-sectional study

Autor: Anousine Homsana, Somphou Sayasone, Dalouny Xayavong, Xuan Duong Tran, Phaivanh Bounsavath, Phoy-Phaylinh Prasayasith, Phimpha Paboriboune, Xaipa-Song Xaiyaphet, Baocher Lianosay, Ikenna C. Eze, Yi-Xiao Lu, Vilayouth Phimolsarn-Nusith, Navalone Andriama-Hefasoa, Sengdavanh Syphan, Banchob Sripa, Peter Odermatt, Malisa Vongsakid, Phout-Tasin Vongngakesone, Nilun-Done Senvanpan, Nan Shwe Nwe Htun, Dimbitsoa Rakotomalala Robinson, Kanchana Thilakoun, Daniel Reinharz, Medea Imboden, Phoum-Savath Ounnavong, Nicole Probst-Hensch
Rok vydání: 2018
Předmět:
Male
Epidemiology
Cross-sectional study
Helminthiasis
Disease
Opisthorchiasis
Feces
Dual burden of disease
chemistry.chemical_compound
Diabetes mellitus
0302 clinical medicine
Risk Factors
Cross-sectional
Prevalence
030212 general & internal medicine
Opisthorchis viverrini
Intestinal Diseases
Parasitic
Anthropometry
biology
lcsh:Public aspects of medicine
General Medicine
Middle Aged
Infectious Diseases
Laos
Regression Analysis
Female
Research Article
Adult
medicine.medical_specialty
030231 tropical medicine
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Lao PDR
Environmental health
medicine
Animals
Humans
Adults
lcsh:RC109-216
Disease burden
Taeniasis
Taenia
business.industry
Opisthorchis
Public health
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
medicine.disease
biology.organism_classification
Cross-Sectional Studies
chemistry
Glycated hemoglobin
business
Zdroj: Infectious Diseases of Poverty
Infectious Diseases of Poverty, Vol 7, Iss 1, Pp 1-11 (2018)
DOI: 10.5451/unibas-ep66808
Popis: Background As a result of epidemiological transition, the health systems of low- and middle-income countries are increasingly faced with a dual disease burden of infectious diseases and emerging non-communicable diseases. Little is known about the mutual influence of these two disease groups. The aim of this study was to investigate the co-occurrence of helminth infections and diabetes mellitus in adults in Lao People’s Democratic Republic (Lao PDR). Methods We conducted a cross-sectional study among 1600 randomly selected adults aged 35 and older from four different socio-economical and ecological provinces. Information on socio-demographics, risk factors and health conditions was obtained from personal interviews. Clinical assessments including anthropometry (height, weight, waist and hip circumference) and blood pressure measurements were also conducted. Diabetes was classified based on self-reported diagnoses and a point-of-care glycated haemoglobin (HbA1c) test from finger prick blood samples. Stool samples for helminth diagnosis were examined with formalin-ether concentration technique for intestinal parasitic infections. The independent associations of helminth infections with diabetic status and HbA1c were assessed using multiple regression analyses. Results The prevalence of pre-diabetes and diabetes was 37.3% and 22.8%, respectively. Fifty-six percent of diabetic cases were undiagnosed and 85% of diagnosed diabetic cases had poor glycemic control. Participants from rural areas and from southern parts of the country had higher infection rates, with Opisthorchis viverrini, being the most common helminth infection (30.5%). We found a positive association between Taenia spp. infections and HbA1c (β = 0.117; 95% CI: 0.042–0.200) and diabetes mellitus risk (OR = 2.98; 95% CI: 1.10–8.05). No other helminth species was associated with glycated hemoglobin. Conclusions Hyperglycaemia and diabetic rates in Lao PDR are alarmingly high, but consistent with other high rates in the region. Given the high rates of under-diagnosis and poorly-controlled glycaemia in diabetes mellitus patients, routine diabetes screening and treatment is essential for the local healthcare system. Large longitudinal cohorts integrating biomarkers are warranted in the search of causal diabetes mellitus risk factors in the region. Common intestinal helminth infections, including O. viverrini, are unlikely to explain the high diabetes mellitus rates observed. Electronic supplementary material The online version of this article (10.1186/s40249-018-0488-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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