Silicon and aluminium interactions in haemodialysis patients
| Autor: | R. G. Parry, J. D. Birchall, P Altmann, Rasheed Ahmad, Andrew Davenport, J.P. Bellia, N.B. Roberts, H T Delves, D Plowman, I. H. Fahal |
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| Rok vydání: | 1998 |
| Předmět: |
inorganic chemicals
Osmosis Silicon medicine.medical_specialty medicine.medical_treatment Hemodialysis Home chemistry.chemical_element Dialysis patients complex mixtures Phosphates End stage renal disease Renal Dialysis Water Supply Aluminium Chronic kidney disease-mineral and bone disorder medicine Humans Renal osteodystrophy Chronic Kidney Disease-Mineral and Bone Disorder Transplantation business.industry Metallurgy respiratory system medicine.disease Hemodialysis Solutions United Kingdom respiratory tract diseases Surgery stomatognathic diseases chemistry Nephrology Kidney Failure Chronic Hemodialysis business Aluminum |
| Zdroj: | Nephrology Dialysis Transplantation. 13:1759-1762 |
| ISSN: | 1460-2385 |
| Popis: | Aluminium toxicity in dialysis patients is well described. Aluminium has a close chemical affinity with silicon. Silicon may have a role in protection against aluminium toxicity.We measured serum aluminium and silicon levels from haemodialysis patients from four different centres.Though no relationship was seen across all centres combined, in one centre there was a reciprocal relationship in patients on home haemodialysis (who did not require reverse osmosis). Median (range) aluminium levels were higher, 2.2 (0.4-9.6) micromol/l when serum silicon was less than 150 micromol/l, and lower, 1.1 (0.2-2.8) micromol/l when serum silicon levels were greater than 150 micromol/l (P = 0.03).In patients treated by haemodialysis without reverse osmosis high serum silicon concentrations were associated with lower serum aluminium concentrations than those with low serum silicon. Further work needs to confirm a preventative role for silicon in the accumulation and subsequent toxicity of aluminium in dialysis patients. |
| Databáze: | OpenAIRE |
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