Ginger Extract Modulates the Expression of Chemokines CCL20 and CCL22 and Their Receptors (CCR6 and CCR4) in the Central Nervous System of Mice with Experimental Autoimmune Encephalomyelitis
| Autor: | Marziyeh Mohammadi-Kordkhayli, Zahra Arabi, Rayhaneh Ahangar-Parvin, Abdollah Jafarzadeh, Maryam Nemati |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Receptors CCR6 Chemokine Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Receptors CCR4 Encephalomyelitis Ginger Extract Central nervous system CCR4 Down-Regulation Ginger Myelin oligodendrocyte glycoprotein 03 medical and health sciences Myelin Mice 0302 clinical medicine Drug Discovery medicine Animals Humans Chemokine CCL22 Chemokine CCL20 biology Plant Extracts Experimental autoimmune encephalomyelitis General Medicine medicine.disease Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Spinal Cord Immunology biology.protein Female Myelin-Oligodendrocyte Glycoprotein 030217 neurology & neurosurgery Rhizome |
| Zdroj: | Drug research. 67(11) |
| ISSN: | 2194-9387 |
| Popis: | Background Chemokines facilitate the leukocytes infiltration into the central nervous system (CNS) which is an essential step in the pathogenesis of multiple sclerosis. Ginger has also a broad anti-inflammatory properties. The aim was to evaluate the effects of ginger extract on the expression of CCL20 and CCL22 and their receptors (CCR6 and CCR4, respectively) in experimental autoimmune encephalomyelitis (EAE). Material and Methods Female C57BL/6 mice used for EAE induction by immunization with myelin oligodendroglial glycoprotein. Then, the EAE mice were treated with PBS or ginger extract, from day +3 to +30. At day 31, mice were scarified and the expression of CCL20 and CCL22 and their receptors in the spinal cord measured using real time-PCR. Results The expression of CCL20, CCL22 and CCR4 in the spinal cord of PBS-administrated EAE mice was significantly higher than healthy group (P Conclusion Treatment of EAE mice with ginger extract down-regulate the expression of CCL20 and CCL22 and their receptors in EAE mice. The possible therapeutic potential of ginger for treatment of MS can be considered in future investigations. |
| Databáze: | OpenAIRE |
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