Specific interaction of some non-steroidal compounds with the progesterone binding site of uteroglobin
| Autor: | Sahib Mk, Shailendra K. Saxena, A.P. Bhaduri, M. Seth |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Stereochemistry
Tritium Biochemistry Non steroidal Benzophenones Structure-Activity Relationship chemistry.chemical_compound Endocrinology Benzophenone Animals Uteroglobin Dithioerythritol Binding site Progesterone Glycoproteins Binding Sites Nonsteroidal biology Ketones chemistry biology.protein Female Rabbits Protein Binding |
| Zdroj: | Journal of Steroid Biochemistry. 18:303-308 |
| ISSN: | 0022-4731 |
| DOI: | 10.1016/0022-4731(83)90107-3 |
| Popis: | Uteroglobin binds progesterone with high affinity. A few substituted diphenyl ketones were observed to inhibit uteroglobin-progesterone binding in a dose-dependent manner. 4,4'-Dimethoxy-2-hydroxy benzophenone had relatively higher affinity for uteroglobin. The structure-activity relationship amongst the substituted diphenyl ketones indicated considerable sensitivity towards minor structural modifications. These observations offer a tool to investigate nonsteroidal compounds in relation to progesterone related functions of uteroglobin in pregnancy. |
| Databáze: | OpenAIRE |
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