Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission
| Autor: | Vanessa Plouffe, Nicolas Piperno, Nguyen-Vi Mohamed, Thibaut Herrou, Nicole Leclerc |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Genetically modified mouse
biology General Neuroscience Tau protein Neurofibrillary Tangles tau Proteins Cell Communication Protein aggregation Entorhinal cortex Endocytosis Mice In vivo Postsynaptic potential Alzheimer Disease Synapses biology.protein Extracellular Animals Humans Secretion Neuroscience |
| Zdroj: | The European journal of neuroscience. 37(12) |
| ISSN: | 1460-9568 |
| Popis: | It is well documented that neurofibrillary tangles composed of aggregated tau protein propagate in a predictable pattern in Alzheimer's disease (AD). The mechanisms underlying the propagation of tau pathology are still poorly understood. Recent studies have provided solid data demonstrating that in several neurodegenerative diseases including AD, the spreading of misfolded protein aggregates in the brain would result from prion-like cell-to-cell transmission. Consistent with this new concept, recent studies have reported that human tau can be released in the extracellular space by an active process of secretion, and can be endocytosed both in vitro and in vivo. Most importantly, it was reported that the spreading of tau pathology was observed along synaptically connected circuits in a transgenic mouse model where human tau overexpression was restricted in the entorhinal cortex. This indicates that secretion of tau by presynaptic neurons and its uptake by postsynaptic neurons could be the sequential events leading to the propagation of tau pathology in the brain. |
| Databáze: | OpenAIRE |
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