Level of Clodronate in Bone after Single and Repeated Subcutaneous Injections in Rats
| Autor: | Thua Österman, Leena Laurén |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Disodium clodronate medicine.medical_specialty Injections Subcutaneous Health Toxicology and Mutagenesis medicine.medical_treatment Absorption (skin) Toxicology Bone and Bones Absorption Subcutaneous injection Pharmacokinetics Internal medicine medicine Animals Distribution (pharmacology) Femur Pharmacology business.industry Dosing regimen Rats Inbred Strains Bisphosphonate Rats Endocrinology Clodronic Acid business |
| Zdroj: | Pharmacology & Toxicology. 69:369-371 |
| ISSN: | 1600-0773 0901-9928 |
| DOI: | 10.1111/j.1600-0773.1991.tb01313.x |
| Popis: | The levels of clodronate in bone and plasma were determined in rats after subcutaneous injection of a mixture of unlabelled and 14C-labelled disodium clodronate as a single dose (25 mg/5 muCi/kg or of 125 mg/25 muCi/kg), and as repeated doses (25 mg/5 muCi/kg) once or five times a week for five weeks. The level of clodronate in bone increased dose-dependently. However, during repeated administration some saturation in bone was observed. The accumulation of clodronate in femur was higher than in ankle. No clear differences in concentration of clodronate in bone could be seen after different dosage schedules when the total doses were the same. |
| Databáze: | OpenAIRE |
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