Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis

Autor: Alois M. Sprinkart, Julian A. Luetkens, René Andrié, Christian Marx, Juergen Gieseke, Rolf Fimmers, Frederic Carsten Schmeel, Darius Dabir, Claas P. Naehle, Daniel Kuetting, Hans H. Schild, Ulrike Schlesinger-Irsch, Jonas Doerner, Daniel Thomas, Christian Stehning, Rami Homsi
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Myocarditis
Adolescent
diagnosis
Magnetic Resonance Imaging (MRI)
Aftercare
Magnetic Resonance Imaging
Cine
Diagnostic Testing
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Imaging
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Edema
medicine
Image Processing
Computer-Assisted
Humans
Prospective Studies
Young adult
mapping
Prospective cohort study
Aged
Original Research
medicine.diagnostic_test
business.industry
Case-control study
follow‐up study
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Acute myocarditis
Case-Control Studies
Acute Disease
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Cardiac magnetic resonance
business
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Cardiac magnetic resonance ( CMR ) can detect inflammatory myocardial alterations in patients suspected of having acute myocarditis. There is limited information regarding the degree of normalization of CMR parameters during the course of the disease and the time window during which quantitative CMR should be most reasonably implemented for diagnostic work‐up. Methods and Results Twenty‐four patients with suspected acute myocarditis and 45 control subjects underwent CMR . Initial CMR was performed 2.6±1.9 days after admission. Myocarditis patients underwent CMR follow‐up after 2.4±0.6, 5.5±1.3, and 16.2±9.9 weeks. The CMR protocol included assessment of standard Lake Louise criteria, T1 relaxation times, extracellular volume fraction, and T2 relaxation times. Group differences between myocarditis patients and control subjects were highest in the acute stage of the disease ( P CMR parameters over the course of the disease ( P P =0.022; T2: 55.5±3.2 ms versus 52.6±2.6 ms; P =0.001). Conclusions In patients with acute myocarditis, CMR markers of myocardial inflammation demonstrated a rapid and continuous decrease over several follow‐up examinations. CMR diagnosis of myocarditis should therefore be attempted at an early stage of the disease. Myocardial T1 and T2 relaxation times were the only parameters of active inflammation/edema that could discriminate between myocarditis patients and control subjects even at a convalescent stage of the disease.
Databáze: OpenAIRE
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