Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity
| Autor: | Kazumasa Iwamoto, Masaya Moriwaki, Michihiro Hide, Ryu Miyake |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Staphylococcus aureus Langerhans cell Virulence Factors Cell Biology medicine.disease_cause Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Immune system Th2 Cells Species Specificity Cell Wall medicine Immunology and Allergy Skin immunity Humans Microbiome Skin integumentary system Microbiota General Medicine Atopic dermatitis medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Immunology Staphylococcal Skin Infections Keratinocyte lcsh:RC581-607 |
| Zdroj: | Allergology International, Vol 68, Iss 3, Pp 309-315 (2019) |
| ISSN: | 1440-1592 |
| Popis: | Atopic dermatitis (AD) is a common chronic skin disease. The presence of the bacterium Staphylococcus aureus (S. aureus) is frequently detected on skin affected with AD. In this review, we focused on the characteristics of S. aureus strains isolated from AD skin, particularly the proteins on the cell surface that modulates the interactions between Langerhans cell, keratinocyte, and S. aureus. The skin microbiome plays an important role in maintaining homeostasis of the skin, and colonization of S. aureus in AD is considered to be deeply involved in the clinical manifestation and pathogenesis of skin flares. Colonizing S. aureus strains in AD harbor different surface proteins at the strain level, which are indicated as clonal complexes. Moreover, the cell wall proteins of S. aureus affect skin adhesion and induce altered immune responses. S. aureus from AD skin (AD strain) exhibits internalization into keratinocytes and induces imbalanced Th1/Th2 adaptive immune responses via Langerhans cells. AD strain-derived cell wall proteins and secreted virulence factors are expected to represent therapeutic targets. In addition, the microbiome on the AD skin surface is associated with skin immunity; thus, microbiome-based immunotherapy, whose mechanism of action completely differs from that of typical steroid ointments, are expected to be developed in the future. Keywords: Atopic dermatitis, Cell wall protein, Clonal complex, Microbiome, Staphylococcus aureus |
| Databáze: | OpenAIRE |
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