Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice
| Autor: | Bo Li, Fu-Chen Zhou, Hai-Ying Jin, Su-Hong Chen, Qiao-Xian Yu, Ying-Jie Dong, Hui-Ying Wang, Gui-Yuan Lv, Rong Luo, Xiang Zheng, Lin-Zi Li, Ning-Yu Zhang, Shan-Shan Lei, Xinglishang He |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Article Subject 03 medical and health sciences chemistry.chemical_compound Other systems of medicine 0302 clinical medicine Internal medicine Nonalcoholic fatty liver disease medicine Carnitine 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Fatty acid metabolism Triglyceride Fatty acid Metabolism Shotgun lipidomics medicine.disease Fatty acid synthase Endocrinology Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) RZ201-999 Research Article medicine.drug |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 |
| Popis: | Dendrobium officinale (DOF) is a traditional Chinese edible and officinal plant. Ultrafine DOF powder (DOFP) can regulate lipids and histopathology in the liver, but the underlying mechanisms of hepatic fatty acid (FA) metabolism, which is generally correlated with the development of nonalcoholic fatty liver disease (NAFLD), remain unclear. The purpose of the present study was to investigate whether DOFP treatment alters hepatic FA metabolism in NAFLD mice by using multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) and analyse the underlying mechanisms. A 3-week DOFP treatment prevented lipid deposition and improved hepatic histopathology in NAFLD mice after withdrawal from the high-sucrose, high-fat (HSHF) diet, and it decreased triglyceride and FA content in the liver. Furthermore, the C16 : 0/C14 : 0 and C18 : 1/18 : 0 ratios in FAs were significantly decreased in the DOFP treatment group, and the C20 : 4/C20 : 3 and C22 : 4/C22 : 3 ratios were increased, and saturated FA was inhibited. Additionally, DOFP treatment significantly increased the content of two FA β-oxidation-related proteins (carnitine palmitoyltransferase 1-α and acyl-coenzyme A oxidase 1). It also decreased the content of a FA synthesis-related protein (fatty acid synthase), a FA desaturation-related protein (stearoyl-coenzyme A desaturase-1), and a FA uptake-related protein (fatty acid transport protein 2). Moreover, DOFP treatment improved dysregulated levels of major phospholipids in the livers of model mice. The results of this study confirm that DOFP treatment in NAFLD mice has liver recovery effects by regulating FA metabolism. |
| Databáze: | OpenAIRE |
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