Increased monoamine turnover in the subfornical organ area following body fluid depletion
| Autor: | Minoru Oda, Masahiro Iwaki, Masahiko Nomura, Katsuhide Kariya, Junichi Tanaka, Koji Hori |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Body fluid medicine.medical_specialty Microdialysis General Neuroscience Dopaminergic Biology Serotonergic Subfornical organ Body Fluids Polyethylene Glycols Rats Endocrinology medicine.anatomical_structure Dopamine Internal medicine Monoaminergic medicine Animals Biogenic Monoamines Serotonin Rats Wistar Dialysis Subfornical Organ medicine.drug |
| Zdroj: | NeuroReport. 3:901-904 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199210000-00020 |
| Popis: | To clarify whether monoaminergic inputs to the subfornical organ (SFO) area participate in fluid regulatory systems, we examined the effects of body fluid depletion on monoamine turnover in the region of the SFO using microdialysis techniques in rats. An iso-osmotic reduction of fluid volume following subcutaneous treatment with polyethylene glycol (PEG) significantly increased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the SFO area. 5-hydroxytryptamine (5-HT) in the SFO area could be detected after the PEG treatment, while 5-HT was undetectable before the treatment. The data imply that both dopaminergic and serotonergic systems in the SFO area may be involved in controlling body fluid balance. |
| Databáze: | OpenAIRE |
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