HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203
| Autor: | V. Csomor, Kornélia Tekes, P. Szegi, Rudolf Laufer, F. Hashemi, Huba Kalász |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Biogenic Amines Serotonin medicine.medical_specialty Cerebellum Time Factors Dopamine medicine.medical_treatment Antidotes Hippocampus Pyridinium Compounds Striatum chemistry.chemical_compound Physiology (medical) Internal medicine Oximes medicine Animals Rats Wistar Antidote Chromatography High Pressure Liquid Chemistry Homovanillic acid Brain Homovanillic Acid General Medicine Hydroxyindoleacetic Acid Rats Endocrinology medicine.anatomical_structure nervous system Anesthesia Medulla oblongata medicine.drug |
| Zdroj: | Acta Physiologica Hungarica. 101:40-46 |
| ISSN: | 1588-2683 0231-424X |
| Popis: | Effect of a new acetylcholine-esterase reactivator, K203 as a new potential antidote in organophosphate intoxications was studied on dopamine (DA), homovanillic acid (HVA), serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels in seven brain regions (cerebellum, spinal cord, hippocampus, hypothalamus, striatum, medulla oblongata and frontal cortex) of rats by an optimized and validated HPLC method. No significant change in brain level of these neurotransmitters was found either 15 or 60 min following treatment. However, when 5-HIAA/5-HT ratios were calculated as measure of turnover, significant decreases were found in the cerebellum, hippocampus, hypothalamus and the frontal cortex 15 min following K203 administration, but after 60 min only in the frontal cortex. |
| Databáze: | OpenAIRE |
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