Hemostatic function of cold‐stored platelets in a thrombocytopenic rabbit bleeding model

Autor: Masayuki Nogawa, Naohide Watanabe, Toshiyasu Koike, Kanae Fukuda, Mariko Ishiguro, Hitomi Fujino, Junichi Hirayama, Masayuki Shiba, Makoto Handa, Takehiko Mori, Shinichiro Okamoto, Shigeki Miyata, Masahiro Satake
Rok vydání: 2022
Předmět:
Zdroj: Transfusion. 62:2304-2313
ISSN: 1537-2995
0041-1132
Popis: Transfusion of cold-stored platelet concentrates (CS-PCs) appears effective in massively bleeding patients. However, few studies have evaluated their in vivo hemostatic function in severe thrombocytopenia.The in vivo function of plasma-depleted human PCs was evaluated in rabbits with a blocked reticuloendothelial system and busulfan-induced thrombocytopenia. On day 1, a human apheresis PC was processed in a platelet additive solution (PAS-PC) and split evenly for cold or room temperature storage (RTS). On days 3, 6, or 9, RTS- or CS-PAS-PCs were transfused (4.0 × 10The mean pre-transfusion rabbit platelet count was 8.6 ± 5.2 × 10CS-PAS-PCs might achieve similar hemostasis as RTS-PAS-PCs in thrombocytopenic patients with mild bleeding. Hemostatic efficacy could be improved by transfusing more CS-PAS-PCs.
Databáze: OpenAIRE
Externí odkaz: