Bridging the Gap Between Morphometric Similarity Mapping and Gene Transcription in Alzheimer’s Disease
| Autor: | Zhonghua Xie, Min Ma, Nan Zhang, Junlin Shen, Yang Zhang, Heng Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allen Human Brain Atlas
General Neuroscience Posterior parietal cortex sMRI = structural MRI Neurosciences. Biological psychiatry. Neuropsychiatry Biology Neurotransmission morphometric similarity gene transcription Correlation medicine.anatomical_structure Cortex (anatomy) Gene expression medicine sense organs Cognitive decline Abnormality Alzheimer’s disease Neuroscience Gene Original Research RC321-571 |
| Zdroj: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience |
| ISSN: | 1662-453X |
| Popis: | Disruptions of brain connectivity have been widely reported in Alzheimer's disease (AD). Morphometric similarity (MS) mapping provides a new way of estimating structural connectivity by inter-regional correlation of T1WI and DTI derived parameters within individual brains. Here, we aimed to identify AD-related MS changing patterns and genes related to the changes and further explore the molecular and cellular mechanism underlying MS changes in AD. Both 3D-T1WI and DTI data of 106 AD patients and well-matched 106 healthy elders from the ADNI database were included in our study. Cortical regions with significantly decreased MS were found in the temporal and parietal cortex, increased MS in the frontal cortex and variant changes in the occipital cortex in AD patients. Mean MS in regions with significantly changed MS was positively or negatively associated with memory function. The negative MS-related genes were significantly down-regulated in AD, specifically enriched in neurons, and participated in biological process with the most significant term in synaptic transmission. This study revealed AD-related cortical MS changes associated with memory function. Linking gene expression to cortical MS changes may provide a possible molecular and cellular substrate for MS abnormality and cognition decline in AD. |
| Databáze: | OpenAIRE |
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