Combined Immunoscore of CD103 and CD3 Identifies Long-Term Survivors in High-Grade Serous Ovarian Cancer
| Autor: | Stefan Stevanovic, Heiko Schuster, Deborah Lam Pham, Hans-Georg Rammensee, Karen Greif, Hans-Christian Bösmüller, Annette Staebler, Christine Beschorner, Falko Fend, Janet Kerstin Peper, Philipp Wagner |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Time Factors CD3 Complex CD3 chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Immunoenzyme Techniques 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Antigens CD Internal medicine Biomarkers Tumor Humans Medicine Survivors Cystadenocarcinoma Survival rate Aged Aged 80 and over Ovarian Neoplasms Tissue microarray biology business.industry Obstetrics and Gynecology FOXP3 hemic and immune systems Middle Aged Prognosis medicine.disease Cystadenocarcinoma Serous Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Intraepithelial lymphocyte Immunohistochemistry Female Neoplasm Grading business Integrin alpha Chains CD8 Follow-Up Studies |
| Zdroj: | International Journal of Gynecologic Cancer. 26:671-679 |
| ISSN: | 1525-1438 1048-891X |
| Popis: | ObjectiveIncreased numbers of tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSC) are associated with improved clinical outcome. Intraepithelial localization of TILs might be regulated by specific homing receptors, such as CD103, which is widely expressed by intraepithelial lymphocytes. Given the emerging role of CD103+ TILs, we aimed to assess their contribution to the prognostic value of immunoscoring in HGSC.MethodsThe density of intratumoral CD3+ and CD103+ lymphocytes was examined by immunohistochemistry on a tissue microarray of a series of 135 patients with advanced HGSC and correlated with CD4+, CD8+, CD56+, FoxP3+, and TCRγ+ T-cell counts, as well as E-cadherin staining and conventional prognostic parameters and clinical outcome.ResultsBoth the presence of CD103+ cells, as well as high numbers of intraepithelial CD3+ lymphocytes (CD3E), showed a significant correlation with overall survival, in the complete series, as well as in patients with optimal debulking and/or platinum sensitivity. Combining CD3 and CD103 counts improved prognostication and identified 3 major subgroups with respect to overall survival. The most pronounced effect was demonstrated for patients with optimally resected and platinum-sensitive tumors. Patients with CD3high/CD103high tumors showed a 5-year survival rate at 90%, CD3low/CD103high at 63%, and CD3low/CD103low at 0% (P < 0.001).ConclusionsThese results suggest that combined assessment of CD103 and CD3 counts improves the prognostic value of TIL counts in HGSC and might identify patients with early relapse or long-term survival based on the type and extent of the immune response. |
| Databáze: | OpenAIRE |
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