Prenatal exposure to testosterone and its precursors influences morphology and later behavioral responsiveness to testosterone of female mice
| Autor: | Nancy J. McDermott, Neal G. Simon, Ronald Gandelman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Period (gene) Male mice Dehydroepiandrosterone Experimental and Cognitive Psychology Biology Mice Behavioral Neuroscience Pregnancy Internal medicine medicine Animals Humans Testosterone Castration Maternal-Fetal Exchange Prenatal exposure Progesterone Behavior Animal Aggression Adult life Endocrinology Pregnenolone Exposure period Female medicine.drug |
| Zdroj: | Physiology & Behavior. 23:23-26 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(79)90116-1 |
| Popis: | Prenatal exposure to testosterone (T), dehydroepiandrosterone or progesterone significantly increased ano-genital distance of female mice. In addition, prenatal exposure to T or pregnenolone significantly reduced the duration of T exposure during adult life required to induced intraspecific fighting behavior. However, the most masculinized females, those exposed to T prenatally, still had significantly shorter ano-genital distances and required a longer exposure period to T in order to establish fighting than did prenatally oil-exposed male mice. Additional experiments revealed that pregnenolone augments later responsiveness to the aggression-promoting property of T only if it is administered during the prenatal period of development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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