The Biochemical Markers Associated with the Occurrence of Coronary Spasm

Autor: Shudong Xia, Liang Li, Yong-Ping Jin, Chao Feng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_specialty
China
Myocardial Infarction
lcsh:Medicine
Coronary Vasospasm
Review Article
030204 cardiovascular system & hematology
General Biochemistry
Genetics and Molecular Biology
Angina Pectoris
Angina
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
Blood test
Humans
Myocardial infarction
Cystatin C
General Immunology and Microbiology
medicine.diagnostic_test
business.industry
Nitrotyrosine
lcsh:R
Vasospasm
General Medicine
medicine.disease
Coronary Vessels
humanities
eye diseases
Acetylcholine
medicine.anatomical_structure
C-Reactive Protein
chemistry
embryonic structures
Cardiology
Biomarker (medicine)
Cytokines
business
human activities
030217 neurology & neurosurgery
Biomarkers
Artery
Lipoprotein
Lipoprotein(a)
Zdroj: BioMed Research International
BioMed Research International, Vol 2019 (2019)
ISSN: 2314-6141
2314-6133
Popis: Coronary artery spasm (CAS) is one of the mechanisms of angina pectoris. Unlike the diagnosis of acute myocardial infarction which is based on the elevation of cardiac markers, the diagnosis of CAS is difficult and sometimes requires sophisticated and risky provocative test which is not widely accepted in China. There is no well-established biomarker for the diagnosis or prediction of CAS. However, there are some biomarkers proven to be associated with the occurrence of CAS. For example, inflammatory factors including C-reactive protein and cytokines, lipoprotein (a), and cystatin-C might be precipitating factor for CAS. Rho-kinase as a mediator involved in multiple mechanisms of CAS, serotonin, and endothelin-1 as powerful vasoconstrictors leading to vasospasm were all observed being elevated in patients with CAS. Thioredoxin and nitrotyrosine reflected the oxidative status and could be observed to be elevated after the occurrence of CAS. In some cases doubted to be CAS without the evidence of provocative test, the blood test for the biomarkers mentioned above could be useful for the diagnosis of CAS.
Databáze: OpenAIRE
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