Cytokines and Oxidative Stress Status Following a Handball Game in Elite Male Players

Autor: Douglas Popp Marin, Rosemari Otton, Beatriz Alves Guerra, Rita de Cássia Santos Macedo, Monica Moreira, Anaysa Paola Bolin
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Oxidative Medicine and Cellular Longevity, Vol 2011 (2011)
ISSN: 1942-0994
1942-0900
Popis: Background. Handball is considered an intermittent sport that places an important stress on a player's aerobic and anaerobic metabolism. However, the oxidative stress responses following a handball game remain unknown. We investigated the responses of plasma and erythrocyte antioxidant system and oxidative stress biomarkers following a single handball game.Methods. Fourteen male elite Brazilian handball athletes were recruited in the present study. Blood samples were taken before, immediately, and 24 hours after the game.Results. After the game and during 24 hours of recovery, the concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (thiol groups and reduced glutathione decreased, whereas TBARS and plasma antioxidant capacity was increased) as well as in erythrocyte (increased levels of TBARS and protein carbonyls). Erythrocyte antioxidant enzyme activities were also significantly changed by handball. Muscle damage indices (creatine kinase and lactate dehydrogenase) increased significantly after exercise. In addition, IL-6 increased after the game, whereas TNF-αdecreased during recovery.Conclusion. This study demonstrates that a single handball game in elite athletes induces a marked state of oxidative stress evidenced by the oxidative modification in plasma and erythrocyte macromolecules, as well as by changes in the enzymatic and nonenzymatic antioxidant system.
Databáze: OpenAIRE
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