The Cross-Link between Ferroptosis and Kidney Diseases
| Autor: | Yaqing Wang, Jingyu Wang, Yi Liu, Li Sun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Programmed cell death Necroptosis Review Article urologic and male genital diseases Bioinformatics Biochemistry Mice medicine Animals Ferroptosis Humans Renal Insufficiency Chronic Kidney QH573-671 urogenital system business.industry Acute kidney injury Cell Biology General Medicine medicine.disease Disease Models Animal medicine.anatomical_structure STRUCTURAL DYSFUNCTION Cytology business Kidney disease |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| DOI: | 10.1155/2021/6654887 |
| Popis: | Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders of the kidney in various etiologies, which significantly affect human survival and social wealth. Nephropathies are often accompanied by various forms of cell death and complex microenvironments. In recent decades, the study of kidney diseases and the traditional forms of cell death have improved. Nontraditional forms of cell death, represented by ferroptosis and necroptosis, have been discovered in the field of kidney diseases, which have reshuffled the role of traditional cell death in nephropathies. Although interactions between ferroptosis and acute kidney injury (AKI) have been continuously explored, studies on ferroptosis and chronic kidney disease (CKD) remain limited. Here, we have reviewed the therapeutic significance of ferroptosis in AKI and anticipated the curative potential of ferroptosis for CKD in the hope of providing insights into ferroptosis and CKD. |
| Databáze: | OpenAIRE |
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