Encephalopathy as a predictor of magnetic resonance imaging abnormalities in asphyxiated newborns
| Autor: | Donna M. Ferriero, J. Colin Partridge, Seth A. Kaufman, A. James Barkovich, Steven P. Miller, David H Glidden |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Pathology Encephalopathy Basal Ganglia Statistics Nonparametric Central nervous system disease Developmental Neuroscience Predictive Value of Tests Internal medicine Basal ganglia medicine Humans Prospective Studies Hypoxia Brain Asphyxia Asphyxia Neonatorum medicine.diagnostic_test business.industry Vascular disease Neonatal encephalopathy Infant Newborn Magnetic resonance imaging equipment and supplies medicine.disease Magnetic Resonance Imaging Neurology Pediatrics Perinatology and Child Health Cardiology Female Neurology (clinical) medicine.symptom business human activities Perinatal Depression |
| Zdroj: | Pediatric Neurology. 28:342-346 |
| ISSN: | 0887-8994 |
| Popis: | Basal ganglia abnormalities on magnetic resonance imaging predict neurodevelopmental impairment in newborns with perinatal depression. We determined the value of a clinical encephalopathy score as a predictor of abnormal magnetic resonance imaging results in newborns with perinatal depression. We assigned a neonatal encephalopathy score to 101 newborns. The encephalopathy score, based on alertness, feeding, tone, respiratory status, reflexes, and seizure activity, was assigned once daily. The maximum score from the first 3 days of life was compared with abnormal magnetic resonance imaging results present globally or solely in the basal ganglia.Eighty-one percent of patients manifested abnormalities on any magnetic resonance imaging sequence, and 37% manifested abnormalities in the basal ganglia alone. The encephalopathy score correlated well with magnetic resonance imaging abnormalities in the basal ganglia (Spearman Rho = 0.335, P0.0001). Newborns with mild and severe encephalopathy had likelihood ratios of 0.41 and 7.4, respectively, for abnormal basal ganglia magnetic resonance imaging results. Newborns with moderate encephalopathy (composing 47% of the cohort) manifested basal ganglia abnormalities with a likelihood ratio of 0.785. Severe clinical encephalopathy correlates with abnormal basal ganglia magnetic resonance imaging results, and mild encephalopathy correlates with a normal magnetic resonance imaging result. However, standard clinical criteria do not alter the prior risk of abnormal basal ganglia magnetic resonance imaging results for newborns with moderate encephalopathy. |
| Databáze: | OpenAIRE |
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